The weekly WAMC public radio show The Best of Our Knowledge features a series of interviews and discussions with faculty, teachers and students associated with the New York Center for Astrobiology, and with visiting speakers in our Seminar series. These segments continue a long tradition of Astrobiology content on WAMC, which began 14 years ago in fall of 1998, sponsored by the Astrobiology Center at Rensselaer Polytechnic Institute and its predecessor, the New York Center for Studies on the Origins of Life, with support from NASA. Past segments are available for online streaming.